Translational development of difluoromethylornithine (DFMO) for the treatment of neuroblastoma

Posted On 2016-01-20 10:30:35

In this review we first discuss the putative cancer cell-directed mechanisms of polyamine depletion activity. Identifying the key mechanism linked to activity provides an opportunity to develop biomarkers predictive of treatment response that can then be used prospectively. Second, we review available evidence that polyamine depletion alters the tumor microenvironment to change it from one that is tumor-permissive through repression of immune system effectors, to one that promotes anti-tumor immunity..