%0 Journal Article %T An evidence-based standardized protocol for anticoagulation following congenital heart surgery %A Deshaies, Catherine %A Poirier, Nancy %A Khairy, Paul %J Translational Pediatrics %D 2018 %B 2018 %9 %! An evidence-based standardized protocol for anticoagulation following congenital heart surgery %K %X Unfractionated heparin is the cornerstone of prevention and treatment of thrombosis in children undergoing cardiac surgery due to its short half-life and reversibility using protamine. Yet, optimal titration in children remains challenging (1). Age-related differences in heparin clearance (2), protein binding activity (3,4) and anti-thrombin concentration (5-8), which are most pronounced in neonates and young infants, obscure the applicability of standard adult dosing protocols. %U https://tp.amegroups.org/article/view/20638 %V 7 %N 4 %P 369-371 %@ 2224-4344