TY - JOUR AU - Narazaki, Hidehiko AU - Asano, Takeshi PY - 2013 TI - Consideration of Glucocorticoids and Escherichia coli -derived L-asparaginase in the treatment of pediatric acute lymphoblastic leukemia JF - Translational Pediatrics; Vol 2, No 2 (April 03, 2013): Translational Pediatrics Y2 - 2013 KW - N2 - Glucocorticoids (GCs) are steroid hormones these are synthesized in the adrenal cortex. After binding to the nuclear glucocorticoid receptor (GR), activated GR complexes play a major role in immune system regulation by exerting a variety of effects such as inhibition of cyclooxygenase and inflammatory cytokines (IL-1, IL-2, IL-5, IL-6, INF-γ) synthesis, neutrophil induction, lymphocyte activation, etc. (1). UR - https://tp.amegroups.org/article/view/1848