TY - JOUR AU - Heksch, Ryan AU - Kamboj, Manmohan AU - Anglin, Kathryn AU - Obrynba, Kathryn PY - 2017 TI - Review of Prader-Willi syndrome: the endocrine approach JF - Translational Pediatrics; Vol 6, No 4 (October 31, 2017): Translational Pediatrics (Focused on Endocrine Disorders) Y2 - 2017 KW - N2 - Prader-Willi syndrome (PWS) is a complex genetic disorder with implications on the endocrine and neurologic systems, metabolism, and behavior. Early in life, PWS is characterized by hypotonia and failure to thrive, followed by obesity and hyperphagia. Patients with PWS develop hypothalamic dysfunction which may lead growth hormone deficiency (GHD), hypogonadism, hypothyroidism, adrenal insufficiency, and poor bone mineral density (BMD). In addition to hypothalamic dysfunction, individuals with PWS have increased risk for obesity which may be complicated by metabolic syndrome and type 2 diabetes mellitus (T2DM). In this paper, we will review the current literature pertaining to the endocrine concerns of PWS and current recommendations for screening and management of these conditions. UR - https://tp.amegroups.org/article/view/16966