%0 Journal Article %T Chromosomal instability syndromes—the most classical and representative types of rare diseases %A Wu, Zhan-He %J Translational Pediatrics %D 2016 %B 2016 %9 %! Chromosomal instability syndromes—the most classical and representative types of rare diseases %K %X As defined, rare diseases including rare childhood cancers are any disorder or condition that is life-threatening or chronically debilitating and is statistically rare with an estimated prevalence of 5 in 10,000 people and the rare diseases are about 80% genetic based in their pathological cause. According to the announcement from national organisation for rare diseases (NORD), 1 in 10 Americans live with a rare disease and they are at high level of symptom complexity so they need special diagnostic and therapeutic strategies. %U https://tp.amegroups.org/article/view/9802 %V 5 %N 2 %P 84 %@ 2224-4344