TY - JOUR AU - Luo, Fang AU - Chen, Zheng AU - Lin, Huijia AU - Wang, Chenhong AU - Ma, Xiaolu AU - Shi, Liping PY - 2014 TI - Evaluation of cerebral function in high risk term infants by using a scoring system based on aEEG JF - Translational Pediatrics; Vol 3, No 4 (October 26, 2014): Translational Pediatrics Y2 - 2014 KW - N2 - Objective: To investigate the relationship between the amplitude integrated electroencephalogram (aEEG) findings and neurodevelopmental outcomes of high-risk term infants with neurological disorders and develop a scoring system for assessment of the cerebral function. Methods: The neurological outcome was assessed at 12- to 18-month of age by using the Bayley Scales of Infant Development II. Valuation of the classification of aEEG background pattern, epileptic electrical activity and sleep-weak cycle (SWC) was conducted to develop a new scoring system. The correlation between the summarized scores and outcome analyzed, and the predictive test of the score system was calculated. Results: A total of 81 infants (39 with asphyxia, 10 with hypoglycemia, 15 with acute bacterial meningoencephalitis, 10 with hyperbilirubinemia and 7 with inborn errors of metabolism) enrolled in the study. The neurological outcome was positive correlated with the background pattern, electrical activity, SWC and summarized scores of the score system based on aEEG. The scoring system has a higher r value, specificity, PPV and lower sensitivity compared with the separate entities such as background pattern, seizures and SWC. The area under the receiver operator characteristics (ROC) curve for predicting outcome by the scoring system was 0.93 (95% CI, 0.878-0.990), with the cut-off value of 7.5. Conclusions: aEEG maybe a potential tool for monitoring cerebral function in term infants at risk for poor neurodevelopmental outcomes. Our proposed scoring system based on aEEG could quantify information provided by aEEG objectively and could be a good predictor for neurological outcome. UR - https://tp.amegroups.org/article/view/4926