TY - JOUR AU - Deshaies, Catherine AU - Poirier, Nancy AU - Khairy, Paul PY - 2018 TI - An evidence-based standardized protocol for anticoagulation following congenital heart surgery JF - Translational Pediatrics; Vol 7, No 4 (October 16, 2018): Translational Pediatrics (The Pediatric Critical Care Continuum—Inside and Outside the Four Walls of the ICU) Y2 - 2018 KW - N2 - Unfractionated heparin is the cornerstone of prevention and treatment of thrombosis in children undergoing cardiac surgery due to its short half-life and reversibility using protamine. Yet, optimal titration in children remains challenging (1). Age-related differences in heparin clearance (2), protein binding activity (3,4) and anti-thrombin concentration (5-8), which are most pronounced in neonates and young infants, obscure the applicability of standard adult dosing protocols. UR - https://tp.amegroups.org/article/view/20638