%0 Journal Article %T Consideration of Glucocorticoids and Escherichia coli -derived L-asparaginase in the treatment of pediatric acute lymphoblastic leukemia %A Narazaki, Hidehiko %A Asano, Takeshi %J Translational Pediatrics %D 2013 %B 2013 %9 %! Consideration of Glucocorticoids and Escherichia coli -derived L-asparaginase in the treatment of pediatric acute lymphoblastic leukemia %K %X Glucocorticoids (GCs) are steroid hormones these are synthesized in the adrenal cortex. After binding to the nuclear glucocorticoid receptor (GR), activated GR complexes play a major role in immune system regulation by exerting a variety of effects such as inhibition of cyclooxygenase and inflammatory cytokines (IL-1, IL-2, IL-5, IL-6, INF-γ) synthesis, neutrophil induction, lymphocyte activation, etc. (1). %U https://tp.amegroups.org/article/view/1848 %V 2 %N 2 %P 73-75 %@ 2224-4344