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Focused Issue: Innovative Technologies and Techniques in Pediatric Cardiac Surgery

In this special issue, we have outstanding contributions from world leaders that concern innovations in surgical procedures (aortic and common atrioventricular valve repairs), perioperative planning and care (three-dimensional printing of models and predictive analytics for postoperative care), cardiopulmonary bypass, and mechanical circulatory support. Furthermore, we have highly innovative contributions regarding mitochondrial transplantation, regenerative medicine, and tissue engineered vascular grafts for pediatric patients with heart disease.

Externally applied compression therapy for Fontan patients

Figure 3 NormaTec PCD action. Initial compression of the feet and ankles results in an upward push of blood volume that is supported by subsequent compartment compressions from 2 to 5. PCD, pneumatic compression device.

TP Annual Report 2017

We are glad to present you the 2017 Annual Report of the journal Translational Pediatrics (TP) here. In the year of 2017, TP has made some progress by the join-efforts of all contributors. More information is shown in the Annual Report.

We also would like to give our sincere thanks to all editorial board members, reviewers, authors and readers. Wish you all a happy, healthy and prosperous 2018!

Focused Issue: Endocrine Disorders

In this Translational Pediatrics issue, we focus on pediatric endocrinology in an effort to provide medical students, residents, primary care providers, and pediatric endocrinologists with numerous high-yield principles relevant to daily patient care and management. The topics covered span a broad array of clinical conditions across multiple age groups, ranging from infancy to young adulthood.

Focused Issue: Clinical Practice of Pediatric Sports Medicine edited by Dr. Dilip R. Patel

The field of pediatric sports medicine has evolved from a wide array of different basic science and clinical disciplines. By its very nature, the practice of sports medicine requires collaboration among multiple disciplines. The goal of this focused issue on the clinical practice of pediatric practice of sports medicine is to provide the reader with basic information on various topics directly relevant to clinical practice.

Adult-onset deletion of the Prader-Willi syndrome susceptibility gene Snord116 in mice results in reduced feeding and increased fat mass

Figure 1 Conditional knockdown of Snord116. Expression levels of hypothalamic Snord116 mRNA in experimental and control mice, detected by in situ hybridisation, demonstrating partial deletion of Snord116. **, P<0.01; data expressed as mean ± SE.

The dilemma of diagnostic testing for Prader-Willi syndrome

Figure 2 The three molecular classes of PWS. Blue chromosome is paternal, pink is maternal. The yellow circle represents the 4–6 Mb critical region for PWS. The open circles indicate an active gene, the red cross an inactive (imprinted) gene. The black box indicates an IC defect. PWS, Prader-Willi syndrome; CI, imprinting centre.

Primary extrapulmonary multidrug-resistant tuberculosis in an immunocompetent child presenting with pleural effusion

Figure 2 CECT chest showing moderate to gross left sided pleural effusion.

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Vol 7, No 3 (July, 2018)

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Focused Issues more

Dr. Manmohan K. Kambo: Endocrine Disorders (Vol 6, No 4, October 2017) More >>

Dr. Dilip R. Patel: Clinical Practice of Pediatric Sports Medicine (Vol 6, No 3, July 2017) More >>

Original Article

3D-printed models optimize preoperative planning for pediatric cardiac tumor debulking

Kyle W. Riggs, Gavin Dsouza, John T. Broderick, Ryan A. Moore, David L. S. Morales

PDF Pages: 196-202 Full Text

Pediatric melanoma and aggressive Spitz tumors: a retrospective diagnostic, exposure and outcome analysis

Kelly M. Bailey, Alison B. Durham, Lili Zhao, Doug Fullen, James Geiger, Carol Bradford, Valerie Opipari, Timothy Johnson, Rajen Mody

PDF Pages: 203-210 Full Text

Chromosomal instability in first trimester miscarriage: a common cause of pregnancy loss?

Philip John Hardy, Kathy Hardy

PDF Pages: 211-218 Full Text

Editorial

Applications of 3D printing in paediatric cardiology: its potential and the need for gathering evidence

Giovanni Biglino, Elena G. Milano

PDF Pages: 219-221 Full Text

High risk HLHS: hybrid approach yes, but how does it work?

Dietmar Schranz

PDF Pages: 222-225 Full Text

Is there any progress in the search for the ideal conduit for reconstruction of the right ventricular outflow tract in young children?

Julie Cleuziou

PDF Pages: 226-228 Full Text

Congenital tracheal stenosis: what should we look at for successful tracheoplasty?

Akiko Yokoi

PDF Pages: 229-232 Full Text

The Fontan extracardiac conduit: one size does not fit all

Frank Cetta, Harold M. Burkhart

PDF Pages: 233-234 Full Text

An investment for the future

Carlo Pace Napoleone

PDF Pages: 235-238 Full Text

Role of stromal cell derived factor-1 in myocardial healing— novel insights from comparative studies in the fetal and postnatal myocardium

Ulrich Hofmann, Stefan Frantz

PDF Pages: 239-241 Full Text

Original Articles

Vitamin D intake in young children with acute lower respiratory infection

Karen S Leis, J Dayre McNally, Matthew R Montgomery, Koravangattu Sankaran, Chandima Karunanayake, Alan M Rosenberg

MRI-DWI improves the early diagnosis of brain abscess induced by Candida albicans in preterm infants

Jian Mao, Juan Li, Dan Chen, Jing Zhang, Ya-Nan Du, Ying-Jie Wang, Xin Li, Rui Wang, Li-Ying Chen, Xiao-Ming Wang

Review Articles

Research advances in neonatal hypoglycemic brain injury

Jun Su, Li Wang

Management of children after renal transplantation: Highlights for general pediatricians

Keith K. Lau, Lucy Giglia, Howard Chan, Anthony K. Chan

Perspective

Fluid therapy of brain edema and intracranial hypertension in children

Pei-Lan Yu

Perspectives

Targeting death receptors: is this trail still hot?

Rajen Mody

Research Highlights

Improving outcomes in childhood T-cell acute lymphoblastic leukemia: promising results from the Children’s Oncology Group incorporating nelarabine into front-line therapy

Lori Muffly, Richard A. Larson

Review Article

Mesenchymal stem cells: potential application in intervertebral disc regeneration

Aiqun Wei, Bojiang Shen, Lisa Williams, Ashish Diwan

Uniparental disomy in Robertsonian translocations: strategies for uniparental disomy testing

Moh-Ying Yip

Genetics of hereditary neurological disorders in children

Yue Huang, Sui Yu, Zhanhe Wu, Beisha Tang

Original Articles

Vitamin D intake in young children with acute lower respiratory infection

Karen S Leis, J Dayre McNally, Matthew R Montgomery, Koravangattu Sankaran, Chandima Karunanayake, Alan M Rosenberg

Cloning and sequence analysis of SLC25A13 transcripts in human amniocytes

Zhan-Hui Zhang, Xin-Jing Zhao, Yuan-Zong Song, Xiao-Mei Tang, Qing-Bing Zha

Review Articles

Management of children after renal transplantation: Highlights for general pediatricians

Keith K. Lau, Lucy Giglia, Howard Chan, Anthony K. Chan

Vitamin D deficiency in surgical congenital heart disease: prevalence and relevance

James Dayre McNally, Kusum Menon

Research Highlight

Children’s Oncology Group L991 final study report: Establishing an important benchmark for assessing late effects of trimodality care of pediatric patients treated for high grade gliomas

Ralph Ermoian, Matthew Ladra, Shilpen Patel

Editorials

Translational Pediatrics—Message from the Editor-in-Chief

Yu-Jia Yang

A step forward in acute lymphoblastic leukemia

Jan Styczynski

Original Articles

A pilot trial on the treatment of gastroesophageal reflux-related cough in infants

Darryl J. Adamko, Carina M. Majaesic, Christopher Skappak, Adrian B. Jones

Cloning and sequence analysis of SLC25A13 transcripts in human amniocytes

Zhan-Hui Zhang, Xin-Jing Zhao, Yuan-Zong Song, Xiao-Mei Tang, Qing-Bing Zha

Pneumatically-driven external pressure applicator to augment Fontan hemodynamics: preliminary findings

Amy L. Throckmorton, Sonya S. Bhavsar, Steven G. Chopski, William B. Moskowitz

Epidemiological survey and analysis of asthma in children aged 0-14 years old in urban and rural areas of Chengdu region

Min Li, Qiong Zhang, Wei-Juan Shi, Lan Li, Yan Li, Ying Pang, Bin Yao, Hong Jiang

Review Articles

The concept and practice of Fanconi Anemia: from the clinical bedside to the laboratory bench

Zhan-He Wu

Editorials

Brain size and neuropsychological functioning in long-term survivors of pediatric acute lymphoblastic leukemia

Jean M. Mulcahy Levy, Stephen P. Hunger

Research Highlights

Pediatric high-grade gliomas: survival at what cost?

Katherine E. Warren

Is quarterly bolus vitamin D₃ supplementation adequate to prevent childhood pneumonia?

Ursula Thiem, Enikö Kállay, Kyra Borchhardt

Original Article

Association of folate metabolism genes MTHFR and MTRR with multiple complex congenital malformation risk in Chinese population of Shanxi

Qin Zhang, Baoling Bai, Xiaozhen Liu, Chunyue Miao, Huili Li

Evaluation of cerebral function in high risk term infants by using a scoring system based on aEEG

Fang Luo, Zheng Chen, Huijia Lin, Chenhong Wang, Xiaolu Ma, Liping Shi

Visuoperceptual sequelae in children with hemophilia and intracranial hemorrhage

Guadalupe Morales, Esmeralda Matute, Erin T. O’Callaghan, Joan Murray, Alberto Tlacuilo-Parra

Methylenetetrahydrofolate reductase polymorphisms at 3'-untranslated region are associated with susceptibility to preterm birth

Qin Zhu, Ying Chen, Jianrong Dai, Benjing Wang, Minjuan Liu, Yun Wang, Jianying Tao, Hong Li

Review Article

Distress and adjustment among adolescents and young adults with cancer: an empirical and conceptual review

Ursula M. Sansom-Daly, Claire E. Wakefield

Preoperative chemotherapy and local stage III in nephroblastoma

Norbert Graf, Rhoikos Furtwängler

Genetics of hereditary neurological disorders in children

Yue Huang, Sui Yu, Zhanhe Wu, Beisha Tang

Preterm birth and single nucleotide polymorphisms in cytokine genes

Qin Zhu, Jian Sun, Ying Chen

Advances and issues in flow cytometric detection of immunophenotypic changes and genomic rearrangements in acute pediatric leukemia

Xin Maggie Wang

Pediatric hepatoblastoma: diagnosis and treatment

Eiso Hiyama

Genetic causes of cancer predisposition in children and adolescents

Federica Saletta, Luciano Dalla Pozza, Jennifer A. Byrne

Down syndrome and leukemia: insights into leukemogenesis and translational targets

Marion K. Mateos, Draga Barbaric, Sally-Anne Byatt, Rosemary Sutton, Glenn M. Marshall

Spanning the genomics era: the vital role of a single institution biorepository for childhood cancer research over a decade

Li Zhou, Daniel Catchpoole

Regenerative medicine therapy for single ventricle congenital heart disease

Chetan Ambastha, Gregory J. Bittle, David Morales, Nathaniel Parchment, Progyaparamita Saha, Rachana Mishra, Sudhish Sharma, Alexander Vasilenko, Muthukumar Gunasekaran, Manal T. Al-Suqi, Deqiang Li, Peixin Yang, Sunjay Kaushal