Consideration of Glucocorticoids and Escherichia coli-derived L-asparaginase in the treatment of pediatric acute lymphoblastic leukemia

Hidehiko Narazaki, Takeshi Asano

Abstract

Glucocorticoids (GCs) are steroid hormones these are synthesized in the adrenal cortex. After binding to the nuclear glucocorticoid receptor (GR), activated GR complexes play a major role in immune system regulation by exerting a variety of effects such as inhibition of cyclooxygenase and inflammatory cytokines (IL-1, IL-2, IL-5, IL-6, INF-γ) synthesis, neutrophil induction, lymphocyte activation, etc. (1).