Article Abstract

Consideration of Glucocorticoids and Escherichia coli-derived L-asparaginase in the treatment of pediatric acute lymphoblastic leukemia

Authors: Hidehiko Narazaki, Takeshi Asano


Glucocorticoids (GCs) are steroid hormones these are synthesized in the adrenal cortex. After binding to the nuclear glucocorticoid receptor (GR), activated GR complexes play a major role in immune system regulation by exerting a variety of effects such as inhibition of cyclooxygenase and inflammatory cytokines (IL-1, IL-2, IL-5, IL-6, INF-γ) synthesis, neutrophil induction, lymphocyte activation, etc. (1).