CINSARC: a new look into an old concept gives hope for new treatments for synovial sarcomas

Genomic instability is a characteristic of all human cancers with its frequency, causes and consequences having been extensively studied and reviewed (1-8). Genomic Instability can be manifested as: whole chromosome aneuploidy that later gives rise to chromosome instability (CIN), gene copy number alterations, structural chromosomal abnormalities like translocations, telomere dysfunction, and gene mutations (9).